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1. Introduction

Cialis (tadalafil) is a phosphodiesterase type 5 inhibitor (PDE5I). It has a long half-life and long-lasting effect, with effects lasting up to 36 hours. It is a phosphodiesterase type 5 inhibitor (PDE5), which primarily increases blood flow in the penis, facilitating the relaxation of muscles, and increasing blood flow in the area for sexual stimulation [

,

].

Cialis has a long half-life of 36 hours [

], which may be the case for patients with benign prostatic hyperplasia (BPH) [

], for example, who require daily or long-term treatment to sustain a satisfactory erection after prolonged use of this drug [

Furthermore, it can cause side effects in some users, such as dizziness and headache, which are more commonly associated with this drug. Patients with BPH who are taking tadalafil or its combination with other phosphodiesterase type 5 inhibitors should not take it, as it has a higher risk of side effects. Similarly, men with ED should not use this drug, as it can cause a serious cardiac adverse reaction, such as QT prolongation and arrhythmia [

A recent meta-analysis of randomized controlled trials of PDE5 inhibitors in the treatment of erectile dysfunction showed that PDE5I use was associated with a lower incidence of ED, although this was not the case for daily use [

However, this meta-analysis was limited by the small number of trials that included men with BPH and a small number of studies that evaluated patients’ ED and the effect of PDE5I use on ED. As such, the meta-analysis results may not be directly comparable to the observed effects of tadalafil. Furthermore, the studies included in the meta-analysis are not prospective, as there were no controlled studies of this type. Therefore, a prospective design would be required.

This study evaluated the effect of daily PDE5I use on erectile function in men with BPH, as well as the effects of PDE5I use on ED and to assess the effects of daily tadalafil on ED and to evaluate the effects of PDE5I use on ED and to assess the effects of PDE5I use on ED and to assess the effects of daily tadalafil on ED and to assess the effects of daily tadalafil on ED. We also evaluated the effects of daily tadalafil on ED and to assess the effects of daily tadalafil on ED and to evaluate the effects of daily tadalafil on ED and to assess the effects of daily tadalafil on ED and to assess the effects of daily tadalafil on ED and to evaluate the effects of daily tadalafil on ED and to evaluate the effects of daily tadalafil on ED and to evaluate the effects of daily tadalafil on ED and to evaluate the effects of daily tadalafil on ED and to evaluate the effects of daily tadalafil on ED and to evaluate the effects of daily tadalafil on ED and to evaluate the effects of daily tadalafil on ED and to evaluate the effects of daily tadalafil on ED and to evaluate the effects of daily tadalafil on ED and to evaluate the effects of daily tadalafil on ED and to evaluate the effects of daily tadalafil on ED and to evaluate the effects of daily tadalafil on ED.

2. Materials and Methods

2.1. Study design and setting

This is a retrospective, observational study that includes men with a diagnosis of BPH who were prescribed tadalafil or its combination with other PDE5 inhibitors. Men were included if they had an erection that lasted more than 4 hours, had a penile erection lasting at least 5 hours, or had a spontaneous erection lasting less than 4 hours. The study period was from January 1st, 2020 to February 1st, 2021.

2.2. Data collection

A detailed medical history, including sex life history, erection-impotence relationship history, and other relevant factors such as age, sex, and medical history, were collected for all men.

Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

for chest pain or use Rectogesic ointment?

• Nicorandil (Ikorel), used to treat angina

• Cimetidine, used to treat stomach or duodenal (peptic) ulcers

• Theophylline, used to treat asthma

• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

• Anti-fungals such as itraconazole and ketoconazole

• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

• Recreational drugs:- amyl nitrate (poppers)

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

Read available consultation questionnaire information

What is Tadalafil?

Tadalafil is the generic version of Cialis. It is available in the USA and is available in the UK and the UK under various brand names.

Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor. It will usually be taken together with a PDE5 inhibitor, such as -, as well as not just taking both directions of the menstrual cycle but also considering the other directions. This means that it will have the job of helping to help you when you are not sure if a tablet is suitable.

It’s important to keep in mind that Tadalafil will only help you when you are strong and when you are sexually stimulated. It is not intended for use in children or as a quick treatment for a rare condition.

How much Tadalafil can you take?

There are many different drugs that can cause the:

• Anorganial conditions such as cervical cancer orRexa | Anorex – Injectable non-steroidal anabolic drugs

• Severe renal impairment or severe liver disease

• Severely impaired have the ability to carry out their daily activities or have special needs the dosage that is required to treat. There is also the

• Drug rash, with or without swelling | Tadalafil – Commonly prescribed medications that are used to treat acne and psoriasis and have at least one of the following effect:

• Erectile dysfunction medication

• High blood pressure medication

• The ability to have sex

• Dizziness or lightheadedness

• Drowsiness or lightheadedness

• Dryness, itching or an‚ever‚an‚upper stomach area – all these conditions may occur simultaneously.

Erectile Dysfunction

Erection problems (impotence) are very common, particularly in men over 40.

Most men occasionally fail to get or keep an erection. This is usually due to stress, tiredness, anxiety or drinking too much alcohol, and it’s nothing to worry about.

If it happens more often, it may be caused by physical or emotional problems.

Physical causes Possible cause Treatment Narrowing of penis blood vessels, high blood pressure, high cholesterol medicine to lower blood pressure, statins to lower cholesterol Hormone problems hormone replacement – for example, testosterone Side effects of prescribed medication change to medicine following discussion with GP You may also be asked to make lifestyle changes.

Do lose weight if you’re overweight stop smoking eat a healthy diet exercise daily try to reduce stress and anxiety

Don’t cycle for a while (if you cycle more than 3 hours a week) drink more than 14 units of alcohol a week

  • Side Effects

    Possible side effects

    Like all medicines, this medicine can cause side effects, although not everybody gets them. These effects are normally mild to moderate in nature.

    If you experience any of the following side effects stop using the medicine and seek medical help immediately:

    allergic reactions including rashes (frequency uncommon). chest pain – do not use nitrates but seek immediate medical assistance (frequency uncommon). priapism, a prolonged and possibly painful erection after taking CIALIS (frequency rare). If you have such an erection, which lasts continuously for more than 4 hours you should contact a doctor immediately. sudden loss of vision (frequency rare). Other side effects have been reported:

    Common (seen in 1 to 10 in every 100 patients)

    headache, back pain, muscle aches, pain in arms and legs, facial flushing, nasal congestion, and indigestion. Uncommon (seen in 1 to 10 in every 1,000 patients)

    dizziness, stomach ache, feeling sick, being sick (vomiting), reflux, blurred vision, eye pain, difficulty in breathing, presence of blood in urine, prolonged erection, pounding heartbeat sensation, a fast heart rate, high blood pressure, low blood pressure, nose bleeds, ringing in the ears, swelling of the hands, feet or ankles and feeling tired. Rare (seen in 1 to 10 in every 10,000 patients)

    fainting, seizures and passing memory loss, swelling of the eyelids, red eyes, sudden decrease or loss of hearing, hives (itchy red welts on the surface of the skin), penile bleeding, presence of blood in semen and increased sweating. Heart attack and stroke have also been reported rarely in men taking CIALIS. Most of these men had known heart problems before taking this medicine.

    Partial, temporary, or permanent decrease or loss of vision in one or both eyes has been rarely reported.

  • that’s not sure?

    Allied to your symptoms, CIALIS has been shown to be effective for about 10%-15% of men over the age of 50.

    CIALIS usually is taken with or without food.

    It is usually administered as an oral tablet.

    Men should not take it more than once every day.

    When taken as a treatment it is important to take it in the correct dose.

    That’s only the beginning

    There is some evidence that taking CIALIS can reduce the risk of stroke, particularly when combined with other hormonal therapies and high blood pressure medications.

    a Onglyfunction virus, which causes serious reflux, is the�s are now being treated with leden. This is a virus that causes lead weight gain, Heart attack and stroke have been reported rarely in this group of men taking CIALIS.

    A study in the U. K. showed that taking CIALIS, even at a much lower dose, ameliorated symptoms of lead in over 65% of men.

    A further six studies in the U. found that taking CIALIS (50mg, 100mg, 200mg, 300mg and 400mg) significantly reduced the number of strokes, heart attacks and all-cause mortality from all causes.

    Men who take CIALIS should stop smoking because it can make them more sensitive to the effects of smoking.

    CIALIS is not recommended for women.

    Cialis 20mg Tablet is used to treat erectile dysfunction (ED) in men and pulmonary arterial hypertension (PAH). It increases blood flow to the penis to help men get an erection. In PAH, it relaxes or widens the blood vessels inside the lungs, which reduces blood pressure in the lungs.

    Cialis 20mg Tablet may be taken on an empty stomach or with a meal. It should be strictly taken as advised by your doctor. The medicine when taken for ED will only help you to get an erection if you are sexually stimulated. You should take it about one hour before you plan to have sex. The amount of time it takes to work varies from person to person, but it normally takes between 30 minutes and one hour. Only take it if you need it and it has been prescribed to you by a doctor. The most common side effects of this medicine are flushing, headache, blurred vision, muscle pain, stomach upset, nausea, back pain, and respiratory tract infection. Talk to your doctor if the side effects bother you or will not go away. Cialis 20mg Tablet can be dangerous to take it along with medicines called nitrates (often given for chest pain). Do not take this medicine if you have severe heart or liver problems, if you have recently had a stroke or heart attack or if you have low blood pressure. Let your doctor know if you suffer from these or any other health problems before taking it. You should not drive if this medicine makes you feel dizzy. Avoid drinking alcohol while taking this medicine as it can lead to side effects.

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